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Decarboxylation of a solution of Orotic acid?

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Jeffrey777:
What would be the best method for decarboxylation of orotic acid?   Can sodium hydroxide be used for this purpose?

hollytara:
Do you have access to the enzyme? 

See  Biochemistry. 2009 Sep 15; 48(36): 8738–8745.
doi: 10.1021/bi901085m

Jeffrey777:
I know there is an enzyme decarboxylase, but this is meant to be an experiment in prebiotic chemistry, showing the formation of uracil when there were no enzymes.

Jeffrey777:
Thanks for the quick reply, btw!

AWK:
https://pubs.acs.org/doi/abs/10.1021/jo01327a020

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