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Questions about carbohydrates!!
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kennywhite:
Hi guys! I've got 3 questions I've been trying to think about and tackle. Was hoping the Ochem community could offer insight on this.
In my ochem class, we learned Lactose intolerance is a very widespread metabolic defect, while Maltose intolerance is a very rare condition. I don't understand why lactose intolerance has a higher incidence. Does it have to do with the fact that for lactose, there is a greater deficiency of beta galactosidase for lactose compared to maltose? Is maltose an alpha glycoside?
Regarding sugar in general, I was curious. So I know all D carbohydrates can't be dextrorotatory. Can a glycoside of a dextrorotatory monosaccharide be levorotatory? It can right? Thanks so much in advance!
hollytara:
You have to think both biologically and chemically to understand the intolerance issue. Lactose intolerance is NOT a metabolic defect. Lactose intolerance is the default condition for adult mammals, as adult mammals generally will not be using milk as a source of nutrition. Certain human populations developed a mutation where lactase (the enzyme that breaks down lactose) activity is maintained into adulthood. This mutation was selected for when combined with the domestication of cows, goats and sheep - it provided an additional source of nutrition to those populations that helped them to survive.
Now lactose is an unusual disacchcarbohydrate for animals as it has a beta glycosidic linkage. That is why it can't be digested by other hydrolase enzymes that hydrolyze alpha linkages. Maltase is one of these - maltose is a disaccharide of two glucose units with an alpha linkage. Starch is a polymer of glucose with alpha linkages. So the major food source for herbivorous mammals (starch) requires an alpha hydrolase - so even if there is some defect in maltase production there are other enzymes that can also do the hydrolysis.
Cellulose has beta linkages - animals can not digest it directly. Those animals that use cellulose as a food source have symbiotic bacteria in their digestive systems that break it down using beta hydrolases.
Yes - the glycoside of a dextrorotatory monosaccharide could be levorotatory. It depends on what alcohol is being used for the glycoside.
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