I synthesize the stannane compound using n-BuLi and Bu3SnCl with aryl halide. I do the experiment and monitor by TLC. Firstly I add n-BuLi,I see that after Lithiation, all starting material changes (new spot appears) so I add Bu3SnCl, but there is no new spot appears(TLC seems not to change when compare with the one when I finish lithiation).
So I wonder that will the TLC change a lot from lithiation (when Li attached) to final product (when Tin attached). Could anyone share your experience?