August 10, 2020, 11:50:13 PM
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Topic: Is this mechanism correct and if it is would it give a good yield?  (Read 329 times)

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Offline JoeyBob

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See below. The product is the racemic compound.

Offline hollytara

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Re: Is this mechanism correct and if it is would it give a good yield?
« Reply #1 on: February 28, 2020, 10:33:42 PM »
It isn't a mechanism, it is a proposed synthesis or synthetic scheme. 

Offline hollytara

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Re: Is this mechanism correct and if it is would it give a good yield?
« Reply #2 on: February 28, 2020, 10:38:45 PM »
Most of the steps are good - but the last two aren't the best.  The imine from the acetophenone and methanamine can be reduced in situ using sodium cyanoborohydride.  Isolating the imine is not always that easy - it can easily hydrolyze. 

Offline JoeyBob

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Re: Is this mechanism correct and if it is would it give a good yield?
« Reply #3 on: February 29, 2020, 12:33:59 AM »
Most of the steps are good - but the last two aren't the best.  The imine from the acetophenone and methanamine can be reduced in situ using sodium cyanoborohydride.  Isolating the imine is not always that easy - it can easily hydrolyze.

Thanks. Toluene is kinda expensive. Is phenylacetone easy to get?

Offline rolnor

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Re: Is this mechanism correct and if it is would it give a good yield?
« Reply #4 on: February 29, 2020, 04:38:15 AM »
Synthesis of amphetamine or other drugs have no place here.

Offline Borek

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Re: Is this mechanism correct and if it is would it give a good yield?
« Reply #5 on: February 29, 2020, 07:14:04 AM »
Please read the forum rules. We have no problems discussing mechanisms, but not synthesis schemes.

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