Please, do not confuse the liberation of the drug bonded with a prodrug carrier via ester hydrolysis in body fluids at a particular pH, with ester hydrolysis in neutral deionized water.
Besides, edible oils and butter are not hydrolyzed in boiling water during cooking; neither polyester-made boats are hydrolyzed at sea.
What things do you know that catalyze the hydrolysis of ester bonds?
Thank you both for your help, it is very much appreciated
So as I understand (
), hydrolysis of an ester has mechanisms which can either be catalysed by base, or by acid.
And since deionised water is neutral, it would not be able to participate in either of these processes to attack the ester bond?
Therefore were I to conduct ultracentrifugal dialysis in water (or even water/ethanol mix) within a 60 minute time period followed by freeze drying, my prodrug ester bond in the compound should remain intact (?)