May 31, 2020, 07:41:25 PM
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Topic: Ortho-Para director question.  (Read 243 times)

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Offline JoeyBob

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Ortho-Para director question.
« on: March 16, 2020, 08:57:36 PM »
If you have an activating substituent that's an ortho-para director, how do you determine if the ortho product is the major product or if the para product is the major product?

Offline chenbeier

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Re: Ortho-Para director question.
« Reply #1 on: March 17, 2020, 05:03:39 AM »
Not easy, depend which groups already existing.

Offline Babcock_Hall

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Re: Ortho-Para director question.
« Reply #2 on: March 17, 2020, 11:16:06 AM »
What factor or factors do you think might come into play?

Offline JoeyBob

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Re: Ortho-Para director question.
« Reply #3 on: March 17, 2020, 04:03:54 PM »
What factor or factors do you think might come into play?

Steric hindrance? So the Para is the primary product?

Offline Babcock_Hall

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Re: Ortho-Para director question.
« Reply #4 on: March 18, 2020, 04:26:50 PM »
I suspect that it depends on the size of the group, but yes, that was what I was thinking as well.

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