April 03, 2020, 08:33:07 PM
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Topic: About pH of the Promethazine HCL salt salution  (Read 107 times)

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Offline adwait

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About pH of the Promethazine HCL salt salution
« on: March 23, 2020, 07:30:50 AM »
I am not that much into organic chemistry or so , and if this is the right place to post but , please help .
Promethazine Hydrochloride(C17H20N2S . HCl) when dissolved as proportion of 25mg/ml . What would be the pH value. And will of that concentration safe for slow IV to humans.

Offline chenbeier

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Re: About pH of the Promethazine HCL salt salution
« Reply #1 on: March 23, 2020, 08:41:52 AM »
pKa is 9.1, so it will be  slight acidic.  Calculate the concentration in mol/l

Calculation with formula of weak base.

http://www.druginfosys.com/drug.aspx?drugCode=623&type=1

Offline AWK

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Re: About pH of the Promethazine HCL salt salution
« Reply #2 on: March 23, 2020, 09:11:57 AM »
IV drugs are buffered and ready to use to humans safely.
AWK

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