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Topic: Solubility of Organic Molecule in Diethyl Ether  (Read 10111 times)

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Offline Sis290025

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Solubility of Organic Molecule in Diethyl Ether
« on: September 10, 2006, 12:57:09 PM »
Is ibuprofen (C13H18O2) insoluble in diethyl ether (C4H10O)? In terms of polarity, is there not a large polarity difference between the two, so there is a greater insolubility?

Thank you for any help.
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Offline russellm72

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Re: Solubility of Organic Molecule in Diethyl Ether
« Reply #1 on: September 11, 2006, 11:24:58 AM »
Try looking in the Merck Index for solubility profile of Ibuprofen....

R.
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Offline Sis290025

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Re: Solubility of Organic Molecule in Diethyl Ether
« Reply #2 on: September 11, 2006, 03:18:08 PM »
I have access to the CRC Handbook; for ibuprofen's solubility, it says it is soluble in water in the liquid phase and is soluble in a locant with an aromatic ring. (Hopefully, my translation of the scientific abbrevations is not wrong.  :-\)
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Offline Sis290025

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Re: Solubility of Organic Molecule in Diethyl Ether
« Reply #3 on: September 13, 2006, 12:54:54 PM »
In the M. Index, it says that ibuprofen is soluble in most orangic solvents but is insoluble in H2O. I don't know how to to apply this general statement to ether.  ???
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Offline russellm72

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Re: Solubility of Organic Molecule in Diethyl Ether
« Reply #4 on: September 14, 2006, 07:26:42 AM »
I would suggest with the substrate being an acid it may well not have a great solubility in ether but perhaps better in solvents such as DCM or EtOAc.

But without looking up more or testing myself one couldn't be sure.

R.
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