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Topic: conversion of chloropropanol to mercaptopropanol  (Read 3755 times)

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Offline awais

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conversion of chloropropanol to mercaptopropanol
« on: September 15, 2006, 03:24:04 AM »
I have 2 questions:

1. I have to convert 1,3-dichloro-2-propanol to 1,3-dimercapto-2-propanol, using some safer method which should not effect the OH group.

2. How to convert the COOH group to ester. compound to be covert is 1,3-dibromo-2-carboxylic acid.

This is really nice forum where i found lot of solutions n i thank all of.
Awais Anwar
Bioorganic Chemistry
University of Saarland, Germany
+49 176 26260734

Offline AWK

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Re: conversion of chloropropanol to mercaptopropanol
« Reply #1 on: September 15, 2006, 05:30:44 AM »
1. I think a formal double exchange reaction with KHS or NaHS will work
2. Use PBr3 followed by an alcohol.
AWK

Offline awais

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Re: conversion of chloropropanol to mercaptopropanol
« Reply #2 on: September 16, 2006, 06:45:10 AM »
Thanks, do u have any procedure, i mean i m not a good chemist
Awais Anwar
Bioorganic Chemistry
University of Saarland, Germany
+49 176 26260734

Offline AWK

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Re: conversion of chloropropanol to mercaptopropanol
« Reply #3 on: September 18, 2006, 03:50:52 AM »
Some excess of reagents are needed. Use anhydrous conditions in the reaction with PBr3.
AWK

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