Hi all - this is not my field so bear with me.
I have a neurological condition called Charcot Marie Tooth disorder (somewhat similar to MS or other degenerative demyelination disorders) and have been doing a lot of research on nutritional factors that might contribute to neuromuscular degeneration. I recently found this along with a slew of other studies linking problems with pyridoxal kinase (PK or PDXK?) metabolization of B6 to similar conditions. This caught my interest because B vitamin treatments I've tried in the past have never yielded desired results and I've never gotten a clear picture why until now. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054113
I can't find resources on how to adjust or supplement PK production in the gut, which has brought me here. If I understand this research correctly, my question is how might one go about enhancing this specific enzymatic process, either through supplementation or diet. I have looked into and tried various diets that emphasize enzyme intake, but can't find anything that is based on an understanding of this specific enzyme and how to boost it.
I hope this makes sense and appreciate any input. Again, not my field, so I apologize if this question doesn't make sense or isn't the right fit for this forum. Just putting out feelers. Many thanks!