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Optimizing a ligand through docking

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Babcock_Hall:
We are doing some covalent docking studies.  Now that we have the results, how do we go about improving our compounds to bind more strongly?  Is it done intuitively or is there a systematic way to work?  I am a docking neophyte.

Babcock_Hall:
I am still working my way through this topic, including the jargon.  I have some articles now on hit-to-lead optimization.

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