[Ditania]

Hello all!!

I'm a translator and I'm trying to understand what a "stretcher" is in order to be able to find a suitable translation. All the texts I've found on the internet talk about the "stretcher" as something well known, but I don't know them!
The text I have to translate talks about methods for making antibody-drug conjugates and a stretcher is part of one of the formulas.
In the text the stretcher is mention as followed:
Str is a stretcher.
In the linker of the Formula, [Str] is selected from the group consisting stretchers based on aliphatic diacids.

Can anybody help me?
Thank you!!!!

[Borek]

I would ask biochemists using the language you are translating to.

[Babcock_Hall]

https://mappingignorance.org/2017/11/27/antibody-drug-conjugates-fine-example-team-work/

A "linker" joins an antibody to a drug.  I am not sure that this is what you mean.

[rolnor]

Is it this you mean?

https://en.wikipedia.org/wiki/Antibody-drug_conjugate

[Ditania]

https://mappingignorance.org/2017/11/27/antibody-drug-conjugates-fine-example-team-work/

A "linker" joins an antibody to a drug.  I am not sure that this is what you mean.

Yes, I understand that the linker joins an antibody to a drug. But what about the stretcher? Is the stretcher some kind of linker?

[Ditania]

Is it this you mean?

https://en.wikipedia.org/wiki/Antibody-drug_conjugate

Yes, my text talks about the Antibody-drug conjugate, but I have troubles to understand what the stretcher is.

[AWK]

If you look at patent US20090175865, there on page 36 is, in my opinion, sufficient explanation that the stretcher is a linker fragment that can consist of: the stretcher unit, a peptide fragment, and a spacer unit. The stretcher is most often a fragment of polyethylene glycol containing up to 24 units, and its role is to reduce the hydrophobicity of the antibody.

[Ditania]

If you look at patent US20090175865, there on page 36 is, in my opinion, sufficient explanation that the stretcher is a linker fragment that can consist of: the stretcher unit, a peptide fragment, and a spacer unit. The stretcher is most often a fragment of polyethylene glycol containing up to 24 units, and its role is to reduce the hydrophobicity of the antibody.

Wow! Thank you! This helped me understand it better.