November 24, 2020, 10:05:17 PM
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Topic: Can piperazine form van-der-Waals interactions?  (Read 236 times)

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Offline MDL

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Can piperazine form van-der-Waals interactions?
« on: September 30, 2020, 06:12:24 AM »
Hi everyone,

I was wondering what's your opinion about the ability of molecules containing polar atoms to form van-der-Waals interactions.

For example piperazine. Each carbon atom is connected to a heteroatom (N), causing partial dipoles. Can it then form attractive van-der-Waals interactions with, for example, a phenyl ring (given a favourable distance)?

To my knowledge, the methyl part of a methoxy group can, at least according to literature.

Any help is greatly appreciated! Thanks  :)


Offline chenbeier

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Re: Can piperazine form van-der-Waals interactions?
« Reply #1 on: September 30, 2020, 06:28:35 AM »
It will be more as van de Waals, Hetereoatoms have polar behavior. So the more negative atom attract to more positive areas.

Offline MDL

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Re: Can piperazine form van-der-Waals interactions?
« Reply #2 on: September 30, 2020, 12:40:05 PM »
Thanks, I agree, but what if the molecule interacting with piperazine is completely apolar? Will they form van-der-Waals interactions?

Offline wildfyr

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Re: Can piperazine form van-der-Waals interactions?
« Reply #3 on: September 30, 2020, 02:34:00 PM »
All organic molecules experience van der waals interactions, its more a matter of degree. Usually "surface area" is a decent stand in for how strong the interaction will be.

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