February 25, 2021, 07:54:57 AM
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Topic: Benzimidazole&benzothiazole comparison  (Read 162 times)

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Offline idis

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Benzimidazole&benzothiazole comparison
« on: December 03, 2020, 01:00:36 PM »
Hey guys, I have the task of comparing the synthesis of benzimidazole and benzothiazole from 1,2-phenylenediamine and 2-aminothiophenol. So far i have found that in general, benzimidazole  formation  takes relatively  longer  time  for  completion  as  compared  to  the  time required  for  benzothiazoles due to the reduced  nucleophilicity  of  –NH  moiety as compared to sulphur atom. Also benzimidazole synthesis does require a stronger oxidant and harsh reaction conditions. Does anyone have any other ideas and examples? Thank you

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