February 08, 2023, 08:43:34 AM
Forum Rules: Read This Before Posting

Topic: The reactivity of Stille coupling reagent  (Read 628 times)

0 Members and 1 Guest are viewing this topic.

Offline Warren

  • Very New Member
  • *
  • Posts: 2
  • Mole Snacks: +0/-0
  • Gender: Male
The reactivity of Stille coupling reagent
« on: January 07, 2021, 01:31:16 AM »
I am a Japanese university student studying organic chemistry.

Stille coupling uses organotin compounds (e.g. ArSnR3). Among them, reagents with R=Me and n-Bu are used.

What are the differences in reactivity due to steric or electronic factors?
Also, which reagent is more reactive, R=Me or n-Bu?

I hope you can answer my questions.

Offline kriggy

  • Chemist
  • Sr. Member
  • *
  • Posts: 1513
  • Mole Snacks: +131/-16
Re: The reactivity of Stille coupling reagent
« Reply #2 on: January 09, 2021, 04:30:12 AM »
IIRC, the trimethyltin reagents are more reactive compared to tributyltin but are also about 100 times more toxic. I was working with those once and read a review which showed numbers and the toxicity was not as high as I thought but still something to consider carefully

Sponsored Links