January 18, 2021, 02:38:16 AM
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Topic: The reactivity of Stille coupling reagent  (Read 178 times)

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Offline Warren

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The reactivity of Stille coupling reagent
« on: January 07, 2021, 01:31:16 AM »
I am a Japanese university student studying organic chemistry.

Stille coupling uses organotin compounds (e.g. ArSnR3). Among them, reagents with R=Me and n-Bu are used.

What are the differences in reactivity due to steric or electronic factors?
Also, which reagent is more reactive, R=Me or n-Bu?

I hope you can answer my questions.


Offline kriggy

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Re: The reactivity of Stille coupling reagent
« Reply #2 on: January 09, 2021, 04:30:12 AM »
IIRC, the trimethyltin reagents are more reactive compared to tributyltin but are also about 100 times more toxic. I was working with those once and read a review which showed numbers and the toxicity was not as high as I thought but still something to consider carefully

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