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Topic: How to properly dissolve melatonin in vegetable glycerine  (Read 2325 times)

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Offline Ryukk9

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How to properly dissolve melatonin in vegetable glycerine
« on: January 14, 2021, 12:04:30 PM »
Hello, Im trying to find a way to properly dissolve melatonin in vegetable glycerin whereas melatonin is dissolving really bad in it. Has anyone some experience with this process ? I´ll be glad for any advice. ;D

Offline Corribus

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Re: How to properly dissolve melatonin in vegetable glycerine
« Reply #1 on: January 14, 2021, 12:29:03 PM »
Speaking from the standpoint of chemistry with no implications intended for actual product development:

First, you need to specify what concentration of solution you are trying to obtain. Everything is soluble in everything to some degree - the question is how much.

Beyond that, the solubility is the solubility - you can't magically make something more soluble just by wishing it so. You can increase solubility by changing the environmental conditions (e.g., heating). You can use a surfactant, which mediates the interactions between the solute and the solvent. Or you can chemically modify the solute so that the solubility is higher - but in that case you may change other properties of the solute as well.

Bear in mind that while solubility is a thermodynamic property, there is a kinetic component as well. The thermodynamic solubility may be higher than what you observe when trying to get something to dissolve simply by adding it to a solvent. You can speed up the dissolution processes by breaking up a solid before adding it using mechanical force (grinding in a mortar and pestle, say) or by applying sheer force to the suspension (sonication). Keep in mind that at very high applied energy, chemical changes to the solute are possible. Heat/cool cycles can also be used to speed up a sluggish dissolution.

What men are poets who can speak of Jupiter if he were like a man, but if he is an immense spinning sphere of methane and ammonia must be silent?  - Richard P. Feynman

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