First post, forgive me if this has been covered before but I haven't managed to stumble across an answer yet.
I'm researching for a dissertation in Mech Eng, with somewhat of a chemistry focus (having been away from study for some time).
I'm looking at desensitising a sensitive compound with the addition of a suitable non-aqueous solvent. As this compound is rather sensitive I'm planning to use a simulant in its place - in order to develop the procedure. The first hurdle is trying to identify a compound which will behave in a similar fashion under dissolution.
1) What property, or collection of properties, is most appropriate for this? I'm aware of the adage 'like dissolves like' but is there a more specific means of measuring this?
Molecular weight and density presumably are important.
I've read a little about Topological Polar Surface Area - is this something worth factoring in?
I understand its a very broad question. Any help to narrow my search down is greatly appreciated!