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How to decapsulate a compound out of micelles?
L v lion:
Hello,
I am developing a redox titration method to assay sodium selenite in a pharmaceutical product. The method that I have developed is a redox back titration with iodine 0.1N and sodium thiosulfate 0.1 N as titration solution. The problem with the titration is that my recovery is to low. After some research it seems that the emulsifiers are forming micelles. This micelles encapsulate the sodium selenite. The emulsifiers are Polysorbate 80 and Sorbitan stearate. Does anyone knows how to decapsulate the sodium selenite out of these emulsifiers?
jeffmoonchop:
Try Triton
shchavel:
Hello!
What method do you use for indication final point of titration? Polysorbate 80 interacts with starch indicator, so it doesn't work with your mixture. Be careful with it.
L v lion:
--- Quote from: jeffmoonchop on April 08, 2021, 11:45:08 AM ---Try Triton
--- End quote ---
I read that Triton is a hazardous chemical. Is there a safer compound that can also work?
L v lion:
--- Quote from: shchavel on April 12, 2021, 02:07:14 AM ---Hello!
What method do you use for indication final point of titration? Polysorbate 80 interacts with starch indicator, so it doesn't work with your mixture. Be careful with it.
--- End quote ---
I am not using a indicator. I am doing the titration with a combination platinum electrode. The final point of the titration is determined potentiometric.
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