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Which step is NOT part of the proton-translocation process in ATP synthase?

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Judy:
Which step is NOT part of the proton-translocation process in ATP synthase?
A) A negatively charged amino acid in each c subunit becomes neutral upon proton binding.
B) A positively charged amino acid in the a subunit forms an ion pair with a charged amino acid in a subunit.
C) deprotonated c subunits are able to interact only with the a  subunit.
D) An arginine in the a subunit is reversibly protonated and deprotonated in each proton binding event.
E) Proton direction is determined by the relative concentrations of protons on either side of the membrane.


I am not quite sure why D is correct. My guess is that arginine being one of the amino acid within ATP synthase can regulate on/off of the enzyme through protonation/deprotonation. Let me know if my thought is reasonable?

Babcock_Hall:
Can arginine form a salt bridge to the side chain of a different amino acid, and if so, what kind of amino acid? 

Judy:

--- Quote from: Babcock_Hall on April 13, 2021, 09:33:50 AM ---Can arginine form a salt bridge to the side chain of a different amino acid, and if so, what kind of amino acid?

--- End quote ---

Arginine can form a salt bridge with negatively charged amino acids.
Thanks for your help.

Babcock_Hall:
Can those negatively charged amino acid side chains bind protons?

Judy:

--- Quote from: Babcock_Hall on April 14, 2021, 09:41:50 AM ---Can those negatively charged amino acid side chains bind protons?

--- End quote ---
Those negatively charge amino acid side chains should be able to bind protons, as opposite charges attract one another. In addition, their binding could potentially help stabilize the entire enzyme. Correct me if I'm wrong, thanks.

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