November 28, 2021, 07:20:56 AM
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Topic: Cyclodextrin Inclusion Complex Stability?  (Read 277 times)

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Offline rava555

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Cyclodextrin Inclusion Complex Stability?
« on: April 19, 2021, 02:18:56 PM »
I'm trying to improve the solubility of silymarin for an experiment by creating an inclusion complex using Hydroxypropyl-β-cyclodextrin.

I have decided to create the complex using a magnetically stirred physical mixture of distilled water, Hydroxypropyl-β-cyclodextrin, and silymarin at 50 Celsius. I will then add acetic acid to bring the PH to 3 as this seems to be PH/temperature that creates the strongest complex in studies.

My question is:

How strong is the cyclodextrin complex? I am thinking of using a low temp dehydrator to dry the mixed solution, and then a grinder to create powder. Will this destroy the complex in any way?

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