I'm trying to create a non-irritating, "gentle" alternative to the famous Nizoral shampoo.
And I simply can't find any skin-friendly, non-toxic solvents that solubilise ketoconazole (KTZ) at concentrations of 2% (or 1%).
I'm purposefully avoiding the sulfates used in Nizoral, even though they're capable of dissolving KTZ.
The only other Ketoconazole shampoo that doesn't use sulfates is Regenpure DR and they are barely able to get the ketoconazole concentration up to 1%.
The things that I've had slight success with are:
- Polysorbate 80
- Reducing the pH
- Ethanol (not suitable for a shampoo formulation)
- Propylene glycol (not suitable for a shampoo formulation)
Any thoughts, ideas, suggestions? All will be greatly appreciated!