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Topic: separating paracetamol and phenylpropanolamine  (Read 975 times)

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Offline luciuscastus

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separating paracetamol and phenylpropanolamine
« on: July 03, 2021, 04:05:04 PM »
So we have a project in which we need to separate paracetamol and phenylpropanolamine. I find it very difficult.
I use acetone to separate off fillers but I ended up with a messy stuff which I can't get rid off on my beaker.
Any thoughts and recommendations for this separation?

Both active ingredients should be separated and isolated.

Offline rolnor

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Re: separating paracetamol and phenylpropanolamine
« Reply #1 on: July 04, 2021, 09:02:50 AM »
The amine can be extracted from organic solvent with a little acid, 5% HCl(aq) is probably fine. To get rid of the mess you can suspend the mixture in MeOH and  filter trough celite. Acetone can react with the amine, not good.

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