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Some help needed for a dissertation on the use of Fluoride in water and dental p

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Biggie2424:
I am in Year 12, going onto Year 13 this September, and I have been working on an EPQ (Extended Project Qualification). To put it simply, it's basically just a dissertation, but there are other admin-related tasks that come with it. My title is: 'To what extent is it safe to use fluoride in water and dental products and should we continue to do so?'. One thing that I wish to explore is the chemistry behind why fluoride can be harmful. However upon doing quite a bit of research, I have found nothing. Is it possible for me to discuss this? Or is it too complicated? If anyone could maybe give me a brief explanation or point me towards some resources that would help me out, I would really appreciate it :)

Borek:
You mean chemistry behind things like dental fluorosis?

Orcio_Dojek:
Concentration of fluorine in drinking water is limited to 1,5 mg / liter in Canada, China and European Union, but to 4,0 mg / liter in the United States.

Higher concentrations of fluorine can be harmful due to the dental or worse - skeletal fluorosis - when fluorine causes substition of Ca3(PO4)2 in bones (Ca3(PO4)2 ----> CaF2)

Babcock_Hall:
It has long been known that fluoride ion inhibits glycolysis, but whether or not this is relevant to your question is not something that I can answer.  You could try a search using PubMed.

Biggie2424:
@Orcio_Dojek Thanks for the help. Can you please explain the substitution of Ca3(PO4)2 in the bones a little bit more? Or refer me to some good sources of information about it? I can't seem to find anything about it anywhere. Thanks!

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