What is the purpose of the PEGylation? Stabilization for delivery? Maybe it isn't needed when expressed in the cell.
That's actually a good question.
While I do know the in's and out's of Interferons, especially Type III IFN Lambda, I don't know much about PEGylation.
I have sort of just assumed that there's a reason why all the human trials have used Pegylated Interferon Lambda, instead of just recombinant human IL-29/IFN-lambda 1 protein.
I assumed it was needed for bioavailability and safety?