September 17, 2021, 09:22:36 PM
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Topic: Esterificaton of Acetic anhydride + alcohols  (Read 170 times)

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Offline lukas.stib

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Esterificaton of Acetic anhydride + alcohols
« on: September 13, 2021, 11:58:14 AM »
Hello chemists,

how does the synthesis of esters of acetic acid from acetic anhydride and alcohols proceed? I should also perform reflux, and then distill the ester, and I should use excess alcohol or acetic anhydride?

Thank you, Lukáš S.

Offline Meter

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Re: Esterificaton of Acetic anhydride + alcohols
« Reply #1 on: September 14, 2021, 01:02:01 PM »
Look up how acid anhydrides react as electrophiles.

Offline Babcock_Hall

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Re: Esterificaton of Acetic anhydride + alcohols
« Reply #2 on: September 14, 2021, 04:51:04 PM »
You might want to pick up a copy of Tietze and Eicher's book, "Reactions and Syntheses in the Organic Laboratory."

Offline rolnor

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Re: Esterificaton of Acetic anhydride + alcohols
« Reply #3 on: September 15, 2021, 12:47:06 AM »
I suggest mix them 1:1 and reflux over night. This should give you a pure product but ditillation can be good if not. This reaction can be exothermic so you should use a large flask and fill it to just 1/5 or so, otherwise the mixture could spurt out from the flask.
« Last Edit: September 15, 2021, 01:08:48 AM by rolnor »

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