Hi, I need a piece of advice. I'm not a newbie in chemistry, but I usually work with relatively large molecules.
In my current project, I'm working with some compounds, which are volatile enough to be at least partially gone during rotary evaporation. Therefore, I have very low isolated yields after initial treatment and subsequent column chromatography.
What are some purification techniques I can use to avoid this?
I'm thinking of trying distillation, but I have relatively small amounts (running reactions on 0.5 to 1 mmol scale for now)...
Thank you in advance.