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Statin drugs-HMG-CoA reductase inhibition

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Rosalind Franklin:
Statin drugs inhibit HMG-CoA reductase enzyme and prevent conversion of Mevalonate to Cholesterol and thereby reduce the cholesterol level in our body but the pathway to conversion of HMG-CoA to Cholesterol involves a lot of different steps and different enzymes, so how do we narrow it down to HMG-CoA reductase only? Why not think of other enzymes to inhibit? How do they figure out which step to inhibit? Is there any reasoning to it?

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