January 17, 2022, 10:37:43 AM
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Topic: Extraction step for synthesis of phenacetin  (Read 199 times)

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Offline tealve

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Extraction step for synthesis of phenacetin
« on: October 31, 2021, 12:57:14 AM »
Hi, I'm very confused on how to write a flow chart for the extraction step of phenacetin synthesis. So we first did a reflux for 1 hour where we added Acetaminophen, ethyl iodide, butanone, and K2CO3. Then we do extraction using dichromomethane (DCM) as the solvent. So I know that we initially are going to have Acetaminophen, ethyl iodide, phenacetin and butanone in the solution (after filtering out all the solid). What I don't understand is what exactly going in the aqueous and the organic layer at each step.

We first added 30ml DCM and 20ml water. Then we extracted aqueous layer with (2 x 10ml) DCM.
Then we washed the combined organic layer with NaOH, H2O and NaCl brine solution.

 

Offline rolnor

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Re: Extraction step for synthesis of phenacetin
« Reply #1 on: October 31, 2021, 05:17:13 AM »
Do you have any suggestion? Why does one wash with NaOH?

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