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Substitution of toluene for benzene in formation of an amide
Babcock_Hall:
Okawara T et al. 1982 Chem. Pharm. Bull. 30(4):1225-1233.
https://www.jstage.jst.go.jp/article/cpb1958/30/4/30_4_1225/_pdf
We will attempt to react a 3-carbon dibrominated acid chloride with aniline to make an amide. The procedure that we will follow uses benzene as the solvent. One of their substrates is quite similar to ours. I was thinking about substituting toluene for benzene but leaving the rest of the procedure unmodified. Does this sound reasonable?
wildfyr:
Should work!
phth:
benzene is not worth working with. Probably the same at the end of the day. Rather handle mercury IMHO.
rolnor:
Toluene, DCM, DCE, it will work.
DrCMS:
--- Quote from: phth on November 03, 2021, 01:56:19 AM ---benzene is not worth working with.
--- End quote ---
but it smells so nice.
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