Chemistry Forums for Students > Organic Chemistry Forum for Graduate Students and Professionals

Substitution of toluene for benzene in formation of an amide

(1/2) > >>

Babcock_Hall:
Okawara T et al. 1982 Chem. Pharm. Bull. 30(4):1225-1233.
https://www.jstage.jst.go.jp/article/cpb1958/30/4/30_4_1225/_pdf
We will attempt to react a 3-carbon dibrominated acid chloride with aniline to make an amide.  The procedure that we will follow uses benzene as the solvent.  One of their substrates is quite similar to ours.  I was thinking about substituting toluene for benzene but leaving the rest of the procedure unmodified.  Does this sound reasonable?

wildfyr:
Should work!

phth:
benzene is not worth working with. Probably the same at the end of the day. Rather handle mercury IMHO.

rolnor:
Toluene, DCM, DCE, it will work.

DrCMS:

--- Quote from: phth on November 03, 2021, 01:56:19 AM ---benzene is not worth working with.

--- End quote ---

but it smells so nice.

Navigation

[0] Message Index

[#] Next page

Go to full version