[Experimental11]

Which of following molecular mechanics steric energy comparisons would be meaningful?

1. cis-butene vs trans-butene

2. 1-butene vs 2-butene

3. chloroethane vs bromoethane

4. staggered butane vs eclipsed butane

5. cyclohexane vs methylcyclopentane

6. axial methylcyclohexane vs equatorial methylcyclohexane



Would I be right to think it's 1, 4, and 6?

[rolnor]

It depends how small energys you are looking for but I think you are right. It would be good for you to look on these molecules in silico and see how they behave. One thing I reacted upon when working in Sybyl is how very large a iodine atom really is, even bromine is very large. A t-butyl group is also very stericaly demanding.