December 05, 2021, 10:15:16 AM
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Topic: Fluorination  (Read 95 times)

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Offline Guitarmaniac86

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Fluorination
« on: November 15, 2021, 12:34:37 PM »
I need a sense check. I have three primary alcohols in a molecule, two tertiary alcohols, an amide and a lactone.


I want to fluorinate the primary alcohols with DAST or deoxofluor but I am concerned that the tertiary alcohols will probably fluorinate. Is this actually possible? I suspect that the primary alcohols will fluorinate much faster than anything else in my molecule.

I am also trying to avoid protecting groups because I want to limit the number of steps, but I do have a route with protecting groups ready to go.


Anyone have any insights on fluorination?
Don't believe atoms, they make up everything!

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