I need a sense check. I have three primary alcohols in a molecule, two tertiary alcohols, an amide and a lactone.
I want to fluorinate the primary alcohols with DAST or deoxofluor but I am concerned that the tertiary alcohols will probably fluorinate. Is this actually possible? I suspect that the primary alcohols will fluorinate much faster than anything else in my molecule.
I am also trying to avoid protecting groups because I want to limit the number of steps, but I do have a route with protecting groups ready to go.
Anyone have any insights on fluorination?