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Transcription and Translation

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Experimental11:
Would it be accurate that if a gene is transcribed into only one mRNA variant, it is possible that it will be translated into more than one protein isoform?

Conversely, would it be accurate to say that an mRNA transcript will always be translated into one protein product?

Babcock_Hall:
Is this a homework problem?  What are your thoughts?

Experimental11:
No, this is not a homework problem, but I want to understand this correctly.

Is an mRNA variant pre or post-splicing? If it is presplicing, then introns/extrons might differ on each mRNA resulting in different mature RNA sequences --> more than one protein isoform.

Babcock_Hall:
I would say that it is concurrent with splicing.  One way to generate two different proteins is either to incorporate or not incorporate a given exon.

Experimental11:
Thanks!

Therefore, are both statements true?

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