[Humr]

Hello. I would like to ask if someone has experience with deprotection of acetal in presence of esters. I  have molecule with 2 acetyls, one propargyl ester and galactose protected with acetons on it.

[rolnor]

Its very hard to avoid hydrolysis of the esters, acetyls are so small. You will get mixture, I am convinced of that. Its bad PG-strategy you have.

[wildfyr]

Acetals are probably less acid stable than ester groups, so you can try a weakly acidic solution for deprotection. Timing will matter.

[Babcock_Hall]

For relatively simple acetals Dowex-50 (H⁺) is sometimes used, because it can be removed by filtration, which is quick and convenient.  However, I don't see how this would completely avoid the problems that wildfyr and rolnor have indicated.

[rolnor]

Its impossible to avoid mixture its bad PG-strategy