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Topic: reaction in forming an amide  (Read 3774 times)

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jenny

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reaction in forming an amide
« on: September 23, 2004, 04:41:49 PM »
In making acetaminophen, the amino group attacks the acetic anhydride, not the hydroxyl group. Why?  Is it that the amino group is more electronegative? Please answer asap. Thanks!  :(

Offline Mitch

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Re:reaction in forming an amide
« Reply #1 on: September 23, 2004, 11:57:02 PM »
It it more nucleophillic
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jenny

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Re:reaction in forming an amide
« Reply #2 on: September 24, 2004, 02:33:48 PM »
Thank you. Organic chem. is so confusing to me, I am glad I found this website, it's awesome.

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