July 01, 2022, 06:48:35 PM
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Topic: 5-fluorouracil synthesis  (Read 156 times)

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Offline PharmaStud.

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5-fluorouracil synthesis
« on: May 05, 2022, 08:52:44 PM »
Hello,

I'm working on 5-fluorouracil and its impurities for a presentation. But I can't find the origin of two of its impurities: 5-methoxyuracil and 2-ethoxy-5-fluorouracil. I have a theory for 5-methoxyuracil but I'm not sure. And for 2-ethoxy-5-fluorouracil I'm still lost, I don't know where it comes from, what reaction it could come from.

I've attached the photo of the mechanism of synthesis of 5-fluorouracil and a reaction which could give us 5-methoxyuracil but I'm not sure about it.

It would help me a lot, if someone could guide me in the right direction :(

Thanks in advance,
Have a nice day !

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