July 01, 2022, 07:57:50 PM
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Topic: chromatography  (Read 143 times)

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Offline natalie5933

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chromatography
« on: June 13, 2022, 10:49:31 PM »
If I want to separate 2 things. Their Rf in the current solvent system is 0.7 and 0.8 i.e. extremely high, not good for separation. Then to lower their Rf should I use a more polar or less polar mobile phase than the one I am using now?? please explain!

Offline rolnor

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Re: chromatography
« Reply #1 on: June 14, 2022, 12:18:14 AM »
Less polar if it is straight-phase silica gel. What system do you use currently? Can you give the structure if your compounds?

https://en.wikipedia.org/wiki/Chromatography

Offline Babcock_Hall

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Re: chromatography
« Reply #2 on: June 14, 2022, 09:48:37 AM »
@OP, Can you provide a simple model that rationalizes this phenomenon?

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