August 10, 2022, 08:01:03 AM
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Topic: amidoxime to oxadiazole  (Read 187 times)

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Offline sharbeldam

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amidoxime to oxadiazole
« on: July 17, 2022, 09:07:24 AM »
Im just looking for a reference for this reaction, i looked up amidoxime reactions, and it looks similar to the reaction of amidoxime with carbonyls (aldehyde/ketone), but here it was with carboxylic acid, Any paper that shows all the reactions of amidoximes? cause if i would have made a guess, i would say that the carboxylic acid can just take a hydrogen from the amine.

Please the reaction name/paper/source would be greatly appreciated
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Offline rolnor

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Re: amidoxime to oxadiazole
« Reply #1 on: July 17, 2022, 03:50:12 PM »
The carboxyl first form a amide with the NH2, then the ring closes as it looses water.

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