September 25, 2022, 01:36:20 AM
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Topic: What pKa should be used to keep a buffer neutral?  (Read 232 times)

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Offline lord farquaad

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What pKa should be used to keep a buffer neutral?
« on: September 10, 2022, 06:16:55 PM »
The objective is to maintain pH = 7.0 for an enzyme-catalyzed reaction that will produce hydrogen ions along with the desired product. At equal concentrations, which weak acid, if any, will serve as the better buffer for the reaction:
acid A with pKa = 6.5, or acid B with pKa = 7.5?

a) acid A
b) acid B
c) water will work as good as either acid
d) both are equally effective

The answer is a) acid A.

I understand that when pKa is higher than pH, deprotonation occurs. Which makes choice a) the correct answer... I just feel like I'm missing something. I guess I'm not sure how adding the acid relates back to creating a buffer. I think I understand but want to be sure. We have a test coming up.
« Last Edit: September 10, 2022, 06:50:25 PM by lord farquaad »

Offline Borek

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Re: What pKa should be used to keep a buffer neutral?
« Reply #1 on: September 11, 2022, 03:32:21 AM »
Think how produced H+ changes amounts of conjugate acid/base in the buffer in both cases.

For what ratio of conjugate acid/base is the buffer most effective?
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