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Topic: Reaction Synthesis Help  (Read 409 times)

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Offline Runvir1632

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Reaction Synthesis Help
« on: January 30, 2024, 08:55:21 PM »
Sorry, i'm new to doing chemical reactions in the lab format. Can someone please explain this calculation? Not sure how much to add of each to reach the equivalents provided. Can someone please run me through this at a ground level so i could do this reaction in lab? Thanks!"To a solution of epoxide with 10 carbon tails (C10) (1,2-epoxydodecane; Sigma-Aldrich), piperazine- and piperidine-containing amines were added at a ratio of 1.2*N:1 epoxide/amine, where N is the number of secondary amine*1 + number of primary amine*2. For example, to synthesize 246C10, to a 5-ml vial, 1 ml of epoxide (4.65 mmol, 4.8 equivalents) was added and 200 μl of amine (0.97 mmol, 1 equivalent) was added dropwise."

Offline billnotgatez

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Re: Reaction Synthesis Help
« Reply #1 on: January 30, 2024, 09:48:20 PM »
@Runvir1632

We post a given question only once on this forum
Please read forum rules before posting
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I deleted your other duplicate post since no one had responded yet


Offline Babcock_Hall

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Re: Reaction Synthesis Help
« Reply #2 on: January 31, 2024, 06:29:16 AM »
I am unclear on what "246" means in your message.  Can you identify the amine that the authors used in some way?  Are you using the same amine or a different amine?

Offline Hunter2

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Re: Reaction Synthesis Help
« Reply #3 on: January 31, 2024, 08:46:33 AM »

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