July 17, 2024, 06:53:59 AM
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Topic: SN2 attack rate change depending on substrate  (Read 2412 times)

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Offline ElectroMaster88

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SN2 attack rate change depending on substrate
« on: March 24, 2024, 02:59:43 PM »
I need to figure out with which molecule out of these two (A or B), NaOH will react faster in a SN2 mechanism.
I've been told that "In general, for SN2 chemistry, nucleophiles may only attack an electrophilic chair when the leaving group is in an axial position", but when I draw the chair conformations, the position of the Br changes depending on if the chair is flipped or not.
I don't know what to do with it.

Offline Babcock_Hall

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Re: SN2 attack rate change depending on substrate
« Reply #1 on: March 25, 2024, 10:35:50 AM »
You wrote "the position of the Br changes..."  Can you explain in detail what you mean?  I have an idea, but I want to make sure that we are on the same page.

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