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Topic: A doubt about GC-MS analysis: number of tests?  (Read 2521 times)

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Offline CarbonSi

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A doubt about GC-MS analysis: number of tests?
« on: April 05, 2024, 01:31:51 AM »
Hello eveyone, I am new on this forum. Please help me about this doubt.
           I want to carry out a GC-MS analysis on a plastic raw material to find out presence or absence of and quantitative analysis of following list of chemicals/impurities.

Please see the PDF file attached.

My doubt is : Should I carry out seperate test for each impurirty or one single GC-MS test will give both qualititative and quantitative analysis of all chemicals?
Like for group of PAHs one seperate test, for Phthalates one seperate test?
Or one single GC-MS analysis/test will give all the information?

Please help me out, I am thinking about such a problem after a long time.
« Last Edit: April 05, 2024, 03:16:29 AM by CarbonSi »

Offline CarbonSi

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Re: A doub about GC-MS analysis: number of tests?
« Reply #1 on: April 05, 2024, 01:45:55 AM »
Like in these reasearch paper hey carried out single test on that Ayurvedic drug and one table/list of chemicals present in the drug was prepared by GC-MS using NIST.

Please see the PDF file attached.
« Last Edit: April 05, 2024, 03:15:31 AM by CarbonSi »

Offline Borek

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Re: A doubt about GC-MS analysis: number of tests?
« Reply #2 on: April 05, 2024, 02:56:14 AM »
Sorry, nobody is going to click on a random link to an unknown file.

Feel free to post the list here, either in the body of the message, or as a pdf attached to the post.
ChemBuddy chemical calculators - stoichiometry, pH, concentration, buffer preparation, titrations.info

Offline CarbonSi

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Re: A doubt about GC-MS analysis: number of tests?
« Reply #3 on: April 05, 2024, 03:13:52 AM »
Sorry, nobody is going to click on a random link to an unknown file.

Feel free to post the list here, either in the body of the message, or as a pdf attached to the post.

I am sorry, I was not aware of the feature that I can upload Pdf directly. This was the first time I was writting a post on this forum. I will upload the files. Thank you for the reply.

Offline marquis

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Re: A doubt about GC-MS analysis: number of tests?
« Reply #4 on: April 05, 2024, 08:01:33 PM »
Sir, I am sorry, but much more testing will usually be required.  Usually, a manufacturer can guide you in the proper course.  Good luck.

Offline rjb

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Re: A doubt about GC-MS analysis: number of tests?
« Reply #5 on: April 08, 2024, 08:02:38 AM »

Should I carry out seperate test for each impurirty or one single GC-MS test will give both qualititative and quantitative analysis of all chemicals?
Like for group of PAHs one seperate test, for Phthalates one seperate test?
Or one single GC-MS analysis/test will give all the information?

Please help me out, I am thinking about such a problem after a long time.

Good Luck,

The bad news is that there is no chance whatsoever that you would be able to develop a universal method applicable for all classes of compounds listed. The fact is, optimum extraction methods will differ between chemical classes, some of these compounds will require derivatization (in the case of organotins something like NaBEt4) whereas others absolutely do not, or would require a very different derivatization regime! That's before you try to contend with developing a method that separates 60+ compounds! Bear in mind that even some existing 'optimised' methods for single compound classes result in co-elution of important compounds, so even then resolution is only possible using MS/MS! 

The good news is that there are a number of methods applicable to one (or possibly more) classes of compound and a quick google of Agilent or Shimadzu application notes should help you find at least some of these. Investing in some reference standards (Agilent do mixtures of PFAS, PAH compounds etc.) would obviously be a necessity, but getting hold of the additional compounds that you will need to produce a quantitative methods is going to be expensive! 

Kind regards

R

Offline CarbonSi

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Re: A doubt about GC-MS analysis: number of tests?
« Reply #6 on: April 22, 2024, 04:12:20 AM »
Thank you for the reply, rjb. I will discuss about it, with you soon.

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