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Topic: about intramolecular claisen condensations  (Read 4125 times)

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Offline a confused chiral girl

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about intramolecular claisen condensations
« on: December 04, 2006, 01:50:20 AM »
Sorry, I have to ask this question without attempting it because I onlyhave 9 mintues to submit this last question in. Please *delete me* ..structures for the carbonyl electrophile and enolate nucleophile that react to give the aldol or enone below.
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Offline Dan

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Re: about intramolecular claisen condensations
« Reply #1 on: December 04, 2006, 04:31:38 AM »
Think intramolecular... work backwards from the product, ie. draw the hydrated precursor, and then diconnect to the enolate
« Last Edit: December 04, 2006, 09:49:34 AM by Dan »
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Offline movies

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Re: about intramolecular claisen condensations
« Reply #2 on: December 04, 2006, 12:50:59 PM »
By the way, that's not a Claisen condensation, it's an aldol condensation.  A Claisen condensation is the attack of an enolate on an ester, then expelling an alkoxide leaving group. to make a 1,3-diketone product.  The intramolecular version of the Claisen condensation is called a Dieckmann cyclization.
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