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Topic: Friedel Crafts Reaction  (Read 4285 times)

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Offline refid

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Friedel Crafts Reaction
« on: April 08, 2007, 02:25:16 PM »
Hello,
 
Just wondering if this FC reaction is possible, given the benzene cation is unstable.

http://bp1.blogger.com/_60ljWjzZHA0/RhkzD0uf4uI/AAAAAAAAARA/wuzB8lADrRg/s1600-h/fc+w.+benzene.JPG

Offline Dan

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Re: Friedel Crafts Reaction
« Reply #1 on: April 08, 2007, 02:50:05 PM »
I'm doubtful.

Suzuki (or perhaps Stille) coupling would be a better approach I think.
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Offline Congenial

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Re: Friedel Crafts Reaction
« Reply #2 on: April 08, 2007, 03:12:08 PM »
Yes chlorobenzene is inert to AlCl3 and sometimes  is used as solvent for some Friedel Crafts reactions.

Offline refid

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Re: Friedel Crafts Reaction
« Reply #3 on: April 08, 2007, 09:21:30 PM »
Yes chlorobenzene is inert to AlCl3 and sometimes  is used as solvent for some Friedel Crafts reactions.

so is what i proposed possible?

Offline Congenial

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Re: Friedel Crafts Reaction
« Reply #4 on: April 09, 2007, 02:08:11 AM »
Impossible, As Dan said, Suzuki coupling is a good selection.

Offline refid

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Re: Friedel Crafts Reaction
« Reply #5 on: April 09, 2007, 09:55:10 PM »
2-bromo Pyrrole + organoboronic benzene = will have a benzene ring attached to C2 position on the pyrrole?

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