April 30, 2024, 12:04:21 AM
Forum Rules: Read This Before Posting


Topic: how to synthes poly(lactide-glycolid)?  (Read 2861 times)

0 Members and 1 Guest are viewing this topic.

Offline wmx2046

  • New Member
  • **
  • Posts: 5
  • Mole Snacks: +1/-1
how to synthes poly(lactide-glycolid)?
« on: April 16, 2007, 02:52:34 AM »
how to synthes poly(lactide-glycolid)? please give me some articles.thank you!!!

Offline HP

  • Chemist
  • Full Member
  • *
  • Posts: 350
  • Mole Snacks: +33/-5
  • Gender: Male
Re: how to synthes poly(lactide-glycolid)?
« Reply #1 on: April 17, 2007, 01:28:20 PM »
Starting from lactic acid (racemic) and converting it by azeotropic distilation with toluene and later vacuum one to yeld racemic mixture of L, D and l,D- lactide (lactone dimeric form of lactic acid).
The same (or similar) with glycolic acid (no isomers) to yeld dimeric lactone called glycolid...So you have the two cyclic monomers which you could polymerize by cationic(preferably and most like with Sn-octanoate as initiator) or anionic Ring opening polymerization to yeld high molecular copolymer...Think about how you can manage the reaction conditions so to make random or block co-polymer. Articles - just google for :)
xpp

Sponsored Links