i wanna synthesize 12-(1-carboxyethylamino)-12-oxododecanoic acid, from dodecanedioic acid and alanine.
what i've thinking of is: firstly using thionyl chloride(SOCl2) to turn odecanedioic acid into dodecanedioyl dichloride, then into the latter alanine be added.
How can i guarantee only one carboxy group of dodecanedioic acid reacts with alanine(i think it may be impossible, so what can i do to make it the major product)?
How should alanine been preprocessed?(ie. is it necessary for the carboxyl group of alanie to be protected, for example using bzl)?
Any suggestion is appriciated! thank u fellows