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Topic: Guanidines from cyanamides  (Read 5710 times)

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Offline islandscience

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Guanidines from cyanamides
« on: June 05, 2007, 01:29:16 PM »
Been trying to follow a prep which involves refluxing an amine  salt and my cyanamide in chlorobenzene but still no luck. Any suggestions?

Offline Custos

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Re: Guanidines from cyanamides
« Reply #1 on: June 05, 2007, 10:27:50 PM »
Hindered amines make this reaction difficult - a Lewis acid like AlCl3 often helps. Check out Organic Synthesis (http://www.orgsyn.org/) Collective Vol 4, page 769.

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