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Topic: Selective reduction of amide carbonyl?  (Read 3531 times)

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Offline Fry

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Selective reduction of amide carbonyl?
« on: June 20, 2007, 05:54:42 AM »
Is it possible to selectively reduce an amide to an amine (not trying to cleave the amide) without touching any other carbonyls in the compound?

Has this been done?
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Offline AWK

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Re: Selective reduction of amide carbonyl?
« Reply #1 on: June 20, 2007, 07:10:02 AM »
Start search literature from:
peptides - J Org Chem. 1976 Apr 2;41(7):1260-1.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):275-82
Rapid and selective reduction of amide group by borane-amine complexes in acyl protected nucleosides.
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