[whawhaxd]

Hi, I'm doing some kind of laboratory experiment on performing

a reaction of thiourea and Merrifield's Resin.

But, it seems I haven't chosen a good solvent for this reaction.

It is quite obvious to find that thiourea is very polar and Merrifield's Resin

is non-polar, and I have chosen to use THF as a solvent.

But, it seems the reaction doesn't take place in THF.

With IR spectrum, it was totally inconclusive, and since the product

didn't dissolve in solvents that I have, I wasn't able to run NMR of it.

So, my question is,

do I need to use a polar solvent? or non-polar solvent (like THF)?

I'm thinking about using DMF which is more polar than THF.

Please help me on this issue guys, thank you~!

[bluemonster]

Dear !
I think u should use polar-solvent, because I think that the reactive side of merrifield's resin (in this case) is carbon (attach to Cl), and it is less reactive  ! so, if u use non-polar solvent, the molecules of solvent will solvate the reactive side of merrifield's resin, and its reactivity decrease quitely ! I think so ! but I am not sure ! can someone help !

regard !